17-Hydroxyprogesterone (17-OHP) is a steroid hormone produced by the adrenal glands and gonads.

It is an intermediate in the synthesis of cortisol.

Clinical uses include:

Diagnosing congenital adrenal hyperplasia (CAH), especially 21-hydroxylase deficiency.

Evaluating adrenal gland function.

Investigating infertility or irregular menstrual cycles in women.

Monitoring treatment in patients with adrenal disorders.

The test is performed using a blood sample, often in the morning when hormone levels are highest.

Analyte: 17-Hydroxyprogesterone hormone in serum/plasma.

Normal Range:

Adults: < 200 ng/dL (varies by lab).

Newborns: Higher levels are common; screening is used for CAH.

Abnormal Findings:

Elevated 17-OHP: Suggests congenital adrenal hyperplasia, adrenal tumors, or ovarian disorders.

Low 17-OHP: May indicate adrenal insufficiency.

Clinical Use:

Confirms suspected CAH.

Helps differentiate causes of hormonal imbalance.

Guides treatment and monitoring of adrenal disorders.