17-Ketogenic Steroids (17-KGS) are urinary metabolites derived mainly from cortisol and other adrenal corticosteroids.

Measurement of 17-KGS provides an indirect assessment of adrenal cortical activity.

Clinical uses include:

Diagnosing Cushing’s syndrome (excess cortisol production).

Detecting Addison’s disease (adrenal insufficiency).

Evaluating pituitary-adrenal axis function.

Monitoring adrenal disorders and treatment response.

The test is performed on a 24-hour urine sample.

Analyte: 17-Ketogenic Steroid metabolites in urine.

Normal Range: ~3–15 mg/24 hr (varies by lab, age, and sex).

Abnormal Findings:

Elevated 17-KGS: Suggests Cushing’s syndrome, adrenal hyperplasia, or stress-related cortisol excess.

Low 17-KGS: Suggests Addison’s disease, pituitary insufficiency, or adrenal suppression.

Clinical Use:

Provides a functional measure of adrenal cortical hormone secretion.

Helps differentiate causes of abnormal cortisol metabolism.

Guides further endocrine evaluation and management.