Anti-dsDNA antibodies are highly specific for systemic lupus erythematosus (SLE).

They are associated with disease activity and severity, particularly lupus nephritis.

Clinical uses include:

Confirming diagnosis of SLE, especially when ANA is positive.

Monitoring disease activity and flares.

Assessing risk of renal involvement in lupus patients.

The test is performed using a blood sample, often alongside ANA and ENA panels.

Analyte: Anti–double-stranded DNA antibodies in serum.

Normal Result: Negative (no detectable anti-dsDNA antibodies).

Abnormal Findings:

Positive anti-dsDNA: Strongly suggests SLE, especially with clinical features.

High titers: Associated with active disease and lupus nephritis.

Clinical Use:

Provides a specific marker for SLE.

Helps differentiate lupus from other autoimmune diseases.

Guides treatment decisions and monitoring of disease progression.