Anti-LKM antibodies are autoantibodies targeting enzymes in liver and kidney microsomes.

They are most commonly associated with autoimmune hepatitis type 2 (AIH-2).

Clinical uses include:

Supporting diagnosis of autoimmune hepatitis type 2.

Differentiating autoimmune hepatitis from other liver diseases.

Occasionally detected in chronic hepatitis C and other autoimmune conditions.

The test is performed using a blood sample, typically via ELISA or immunofluorescence methods.

Analyte: Anti-LKM antibodies in blood serum.

Normal Result: Negative (no Anti-LKM antibodies detected).

Positive Result: Presence of Anti-LKM antibodies → suggests autoimmune hepatitis type 2 or related liver disease.

Clinical Use:

Confirms autoimmune hepatitis type 2.

Helps differentiate between autoimmune and viral hepatitis.

Guides treatment decisions and monitoring in autoimmune liver disease.