Ceruloplasmin is a glycoprotein synthesized in the liver that binds and transports copper in the bloodstream.

It plays a role in iron metabolism and acts as an acute-phase reactant.

Clinical uses include:

Diagnosing Wilson’s disease (low ceruloplasmin with copper accumulation in tissues).

Evaluating copper deficiency or overload.

Supporting diagnosis of Menkes disease and other rare metabolic disorders.

Assessing liver function and certain inflammatory conditions.

The test is performed using a blood sample.

Analyte: Ceruloplasmin concentration in serum.

Normal Range (approximate, varies by lab): 20 – 60 mg/dL.

Abnormal Findings:

Low ceruloplasmin: Suggests Wilson’s disease, copper deficiency, or severe liver disease.

High ceruloplasmin: May occur in pregnancy, oral contraceptive use, or inflammatory states.

Clinical Use:

Provides a specific marker for copper metabolism disorders.

Helps differentiate causes of liver dysfunction.

Guides treatment and monitoring in metabolic and hepatic conditions.