Estradiol (E2) is the primary estrogen hormone in both women and men.

It plays a key role in menstrual cycle regulation, fertility, bone health, and secondary sexual characteristics.

Clinical uses include:

Assessing ovarian function and menstrual irregularities.

Monitoring fertility treatments and ovulation induction.

Evaluating menopause status.

Detecting hormone-secreting tumors.

Supporting diagnosis of delayed puberty or hypogonadism.

The test is performed using a blood sample.

Analyte: Estradiol (E2) concentration in blood serum.

Normal Range: Varies by sex, age, and menstrual cycle phase.

Women (follicular phase): ~20–350 pg/mL

Women (mid-cycle peak): ~150–750 pg/mL

Women (luteal phase): ~30–450 pg/mL

Postmenopausal women: < 20 pg/mL

Men: ~10–50 pg/mL

Low Levels: May indicate ovarian failure, menopause, or hypogonadism.

High Levels: May suggest ovarian tumors, estrogen therapy, or pregnancy.

Clinical Use:

Evaluates reproductive and endocrine health.

Monitors fertility treatments.

Assists in diagnosing hormonal disorders.