G6PD is an enzyme that protects red blood cells from oxidative damage.
A deficiency can lead to hemolysis (breakdown of red blood cells) when exposed to certain foods, infections, or medications (e.g., antimalarials, sulfa drugs, fava beans).
The qualitative test determines whether G6PD activity is normal or deficient, rather than providing an exact enzyme level.
Clinical uses include:
Diagnosing G6PD deficiency in patients with unexplained anemia or jaundice.
Screening before prescribing drugs known to trigger hemolysis.
Identifying carriers in families with a history of G6PD deficiency.
The test is performed using a blood sample.