HDL cholesterol is known as the “good cholesterol” because it helps remove excess cholesterol from the bloodstream and transports it to the liver for excretion.

The direct method allows accurate measurement of HDL without requiring prior separation of other lipoproteins.

Clinical uses include:

Assessing risk of cardiovascular disease (CVD).

Monitoring patients with hyperlipidemia.

Evaluating effectiveness of lipid‑lowering therapy.

Supporting overall lipid profile interpretation.

Often performed alongside Total Cholesterol, LDL, Triglycerides, and VLDL for a complete lipid panel.

Analyte: Serum HDL cholesterol concentration (mg/dL).

Normal Range (varies by lab):

Men: > 40 mg/dL

Women: > 50 mg/dL

Abnormal Findings:

Low HDL (< 40 mg/dL): Increased risk of cardiovascular disease, metabolic syndrome, diabetes.

High HDL (> 60 mg/dL): Generally protective against heart disease.

Clinical Use:

Provides a direct measure of protective cholesterol fraction.

Helps guide treatment decisions in lipid disorders.

Supports risk stratification for atherosclerosis and heart disease.