HCV RNA PCR (Polymerase Chain Reaction) is a molecular test that identifies viral genetic material (RNA).

The qualitative format determines whether HCV RNA is present or absent, without measuring viral load.

Clinical uses include:

Confirming active HCV infection after a positive antibody test (ELISA/CLIA/Card).

Differentiating between past exposure and current infection.

Supporting diagnosis in patients with unclear serology results.

Guiding decisions for antiviral therapy initiation.

Often followed by HCV RNA quantitative PCR to measure viral load and monitor treatment response.

Analyte: Hepatitis C Virus RNA in serum/plasma.

Normal Result: Not detected (negative).

Abnormal Findings:

Detected (positive): Indicates active HCV infection.

Not detected (negative): Suggests no active infection (may indicate past infection or successful treatment).

Clinical Use:

Provides a definitive marker of active HCV infection.

Helps prevent false positives from antibody tests.

Supports treatment planning and patient counseling.