IL‑6 is a pro‑inflammatory cytokine produced by immune cells, endothelial cells, and fibroblasts.

It plays a key role in acute phase response, immune regulation, and hematopoiesis.

Clinical uses include:

Assessing systemic inflammation in infections, sepsis, and autoimmune diseases.

Monitoring cytokine storm in severe viral infections (e.g., COVID‑19).

Supporting diagnosis and prognosis in rheumatoid arthritis, lupus, and other autoimmune conditions.

Evaluating cancer progression (e.g., multiple myeloma, lymphoma).

Often performed alongside CRP, ESR, TNF‑α, and other cytokine assays for comprehensive evaluation.

Analyte: Interleukin‑6 (IL‑6) concentration in serum/plasma (pg/mL).

Normal Range (varies by lab): Typically <7 pg/mL in healthy individuals.

Abnormal Findings:

Elevated IL‑6: Indicates active inflammation, infection, autoimmune disease, or malignancy.

Very high levels: Associated with sepsis, cytokine storm, or severe systemic disease.

Clinical Use:

Provides a sensitive marker of inflammation and immune activation.

Helps guide diagnosis, monitoring, and treatment planning.

Supports immunology, rheumatology, oncology, and infectious disease evaluations.