LE cells are neutrophils or macrophages that have ingested the denatured nuclear material of another cell.

The test was historically used to support the diagnosis of systemic lupus erythematosus (SLE).

Today, it is largely replaced by more specific tests such as ANA (antinuclear antibody) and anti-dsDNA antibody tests.

Clinical uses include:

Detecting autoimmune activity in suspected lupus cases.

Supporting diagnosis of connective tissue diseases.

Providing historical reference in autoimmune testing.

The test is performed using a blood sample and microscopic examination.

Analyte: Presence of LE cells in blood smear.

Normal Result: No LE cells detected.

Abnormal Result: LE cells present → suggests autoimmune activity, especially lupus.

Clinical Use:

Helps confirm lupus diagnosis (though rarely used today).

Supports evaluation of autoimmune disorders.

Provides supplementary information alongside modern antibody tests.