Leptospirosis is a zoonotic bacterial infection caused by Leptospira species, often transmitted through contaminated water or soil.

The IgM antibody is the first to appear after infection and indicates recent or active disease.

Clinical uses include:

Confirming acute leptospirosis in symptomatic patients.

Supporting diagnosis in endemic areas with exposure history.

Differentiating leptospirosis from other febrile illnesses (e.g., dengue, malaria, typhoid).

The test is performed using a blood sample, typically by ELISA or rapid immunoassay.

Analyte: IgM antibodies against Leptospira bacteria.

Result Interpretation:

Positive IgM: Suggests recent or ongoing leptospira infection.

Negative IgM: No evidence of acute infection (may require repeat testing if early stage).

Clinical Use:

Detects acute leptospirosis.

Helps guide treatment decisions.

Supports diagnosis alongside clinical symptoms and other lab findings (CBC, LFT, RFT).