Non‑HDL cholesterol includes all cholesterol types that can contribute to plaque buildup in arteries (LDL, VLDL, IDL, lipoprotein(a)).

Considered a better predictor of cardiovascular disease risk than LDL alone.

Clinical uses include:

Assessing risk of atherosclerosis, coronary artery disease, and stroke.

Monitoring patients on lipid‑lowering therapy.

Supporting preventive health screening.

Often performed as part of a lipid profile alongside total cholesterol, LDL, HDL, and triglycerides.

Analyte: Non‑HDL cholesterol (mg/dL), calculated as:

Non‑HDL Cholesterol
=
Total Cholesterol
−
HDL Cholesterol
Normal Range (varies by lab):

Optimal: < 130 mg/dL

Borderline high: 130–159 mg/dL

High: 160–189 mg/dL

Very high: ≥ 190 mg/dL

Abnormal Findings:

High Non‑HDL cholesterol: Increased risk of cardiovascular disease.

Low Non‑HDL cholesterol: Generally favorable lipid profile.

Clinical Use:

Provides a comprehensive marker of atherogenic cholesterol particles.

Helps guide dietary, lifestyle, and pharmacological interventions.

Supports long‑term monitoring of lipid disorders.