Angiotensin-Converting Enzyme (ACE) is produced mainly in the lungs and plays a role in blood pressure regulation.

Elevated ACE levels are often associated with sarcoidosis, a disease characterized by granuloma formation.

Clinical uses include:

Supporting diagnosis of sarcoidosis.

Monitoring disease activity and treatment response.

Evaluating other conditions such as tuberculosis, leprosy, hyperthyroidism, and certain liver diseases.

The test is performed using a blood sample.

Analyte: Angiotensin-Converting Enzyme (ACE) in serum.

Normal Range: ~8–52 U/L (varies by lab).

Elevated Levels:

Suggestive of sarcoidosis or other granulomatous diseases.

May also be seen in liver disease, diabetes, or hyperthyroidism.

Low Levels:

May occur in chronic obstructive pulmonary disease (COPD) or after ACE-inhibitor therapy.

Clinical Use:

Helps in diagnosis and monitoring of sarcoidosis.

Provides supportive evidence for granulomatous or inflammatory conditions.

Guides treatment decisions and follow-up.