Ceruloplasmin is a glycoprotein that binds and transports copper in the blood.

It plays a role in iron metabolism and acts as an antioxidant.

Clinical uses include:

Diagnosing Wilson’s disease (low ceruloplasmin levels).

Evaluating copper deficiency or overload.

Supporting diagnosis of liver disease and neurodegenerative disorders.

Monitoring patients with suspected metabolic or nutritional abnormalities.

The test is performed using a blood sample.

Analyte: Ceruloplasmin concentration in blood serum.

Normal Range: ~20 – 60 mg/dL (varies slightly by lab).

Low Levels:

Strongly suggest Wilson’s disease (impaired copper transport).

May indicate copper deficiency, malnutrition, or liver disease.

High Levels:

May occur in pregnancy, inflammation, infection, or certain cancers (ceruloplasmin is an acute-phase reactant).

Clinical Use:

Detects abnormalities in copper metabolism.

Supports diagnosis of Wilson’s disease and related disorders.

Guides treatment and monitoring of liver and metabolic conditions.