The TC/HDL ratio is a widely used indicator of lipid balance and cardiovascular risk.

Total Cholesterol (TC) includes LDL, HDL, VLDL, and other cholesterol fractions.

HDL cholesterol is protective (“good cholesterol”), while higher TC levels increase risk.

Clinical uses include:

Assessing risk of coronary artery disease (CAD).

Monitoring patients with hyperlipidemia.

Evaluating effectiveness of lipid‑lowering therapy.

Supporting overall cardiac risk stratification.

Often interpreted alongside LDL, Triglycerides, and VLDL for a complete lipid profile.

Analyte: Ratio of Total Cholesterol (mg/dL) to HDL Cholesterol (mg/dL).

Normal Range (varies by lab):

Ideal: < 3.5

Moderate risk: 3.5–5.0

High risk: > 5.0

Abnormal Findings:

High TC/HDL ratio: Indicates increased risk of atherosclerosis and cardiovascular disease.

Low TC/HDL ratio: Suggests protective lipid profile and lower cardiac risk.

Clinical Use:

Provides a simple, reliable measure of cardiovascular risk.

Helps guide preventive and therapeutic interventions.

Supports monitoring of lipid management strategies.