Proteins are essential for cell structure, enzyme activity, hormone transport, and immune defense.
The test reflects the balance between albumin (major plasma protein) and globulins (immune and transport proteins).
Clinical uses include:
Assessing nutritional status.
Evaluating liver disease, kidney disease, and chronic infections.
Supporting diagnosis of immune disorders and multiple myeloma.
Monitoring patients with protein‑losing conditions (e.g., nephrotic syndrome, malabsorption).
Often performed alongside albumin, globulin, and A/G ratio tests for a complete protein profile.