Transferrin is the main iron‑binding protein in the blood, produced by the liver.

It regulates iron transport to cells and storage sites.

Clinical uses include:

Diagnosing iron deficiency anemia.

Differentiating between iron deficiency and anemia of chronic disease.

Assessing nutritional status and liver function.

Supporting evaluation of iron overload disorders (e.g., hemochromatosis).

Often performed alongside serum iron, ferritin, and TIBC (Total Iron Binding Capacity) for a complete iron profile.

Analyte: Transferrin concentration in serum (mg/dL).

Normal Range (varies by lab): ~200–360 mg/dL.

Abnormal Findings:

High transferrin: Suggests iron deficiency anemia (more binding sites available due to low iron).

Low transferrin: Seen in anemia of chronic disease, liver disease, malnutrition, or iron overload.

Clinical Use:

Provides a direct measure of iron transport protein levels.

Helps guide diagnosis and management of anemia and iron disorders.

Supports hematology, internal medicine, and nutrition evaluations.