Transferrin is the main protein that transports iron in the blood.

Transferrin saturation reflects the proportion of transferrin binding sites occupied by iron.

Clinical uses include:

Diagnosing iron deficiency anemia.

Detecting iron overload conditions such as hemochromatosis.

Differentiating between iron deficiency and anemia of chronic disease.

Monitoring patients with nutritional deficiencies or chronic illness.

Often performed alongside serum iron, ferritin, and TIBC (Total Iron Binding Capacity) for a complete iron profile.

Analyte: Transferrin Saturation (%) = (Serum Iron ÷ TIBC) × 100.

Normal Range (varies by lab): ~20–50%.

Abnormal Findings:

Low saturation (<15%): Suggests iron deficiency anemia.

High saturation (>50%): Indicates iron overload (e.g., hemochromatosis, iron poisoning).

Clinical Use:

Provides a direct measure of iron transport and availability.

Helps guide diagnosis and management of anemia and iron disorders.

Supports hematology, internal medicine, and nutrition evaluations.