Syphilis is a sexually transmitted infection caused by Treponema pallidum.

The VDRL test is a non‑treponemal screening test, while ELISA is a treponemal‑specific confirmatory test.

VDRL ELISA provides enhanced sensitivity and specificity compared to traditional VDRL alone.

Clinical uses include:

Screening and confirmation of syphilis infection.

Monitoring treatment response in syphilis patients.

Supporting diagnosis in patients with neurological or atypical presentations.

Often performed alongside FTA‑ABS, TPHA, and rapid treponemal tests for comprehensive evaluation.

Analyte: Antibodies against Treponema pallidum in serum.

Normal Result: Negative (no antibodies detected).

Abnormal Findings:

Positive result: Indicates current or past syphilis infection.

False positives: May occur in autoimmune diseases, pregnancy, or other infections.

Clinical Use:

Provides a sensitive and specific marker for syphilis diagnosis.

Helps guide screening, confirmation, and treatment monitoring.

Supports infectious disease, dermatology, and sexual health evaluations.