Vitamin B‑12 (cobalamin) is essential for red blood cell formation, DNA synthesis, and neurological function.

Deficiency can lead to megaloblastic anemia, neuropathy, and cognitive impairment.

Clinical uses include:

Diagnosing Vitamin B‑12 deficiency.

Evaluating patients with anemia, weakness, or neurological symptoms.

Monitoring nutritional status in vegetarians, vegans, and elderly individuals.

Supporting diagnosis of pernicious anemia and malabsorption syndromes.

Often performed alongside Folate, Homocysteine, and Methylmalonic Acid (MMA) tests for comprehensive evaluation.

Analyte: Vitamin B‑12 (cobalamin) in serum (pg/mL).

Normal Range (varies by lab): ~200–900 pg/mL.

Abnormal Findings:

Low Vitamin B‑12: Suggests deficiency due to poor intake, pernicious anemia, or malabsorption.

High Vitamin B‑12: May occur in liver disease, myeloproliferative disorders, or supplementation.

Clinical Use:

Provides a direct marker of Vitamin B‑12 status.

Helps guide diagnosis, treatment, and monitoring of anemia and neurological disorders.

Supports hematology, neurology, internal medicine, and nutrition evaluations.